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ID 49892
file
creator
HORIKAWA, Yoshiya
subject
Lactobacillus casei ointment
Thermal injury
Opportunistic infection
NDC
Medical sciences
abstract
I studied the effects of LC ointment made of Solbase and heat-killed Lactobacillus casei YIT 0003 on the healing of thermal injury wounds and the elimination of bacteria from infected wounds in mice. LC ointment promoted the healing of the uninfected thermal injury wounds and thermal injury wounds infected with Pseudomonas aeruginosa alone or with mixed bacterial suspension of Staphylococcus aureus, Escherichia coli and P. aeruginosa and resulted in the elimination of infecting bacteria. Histopathologically, the formation of collagen fibers in wounded subcutaneous tissues to which LC ointment was applied was more remarkable than that of tissues treated with Solbase (ointment base). The clearance of bacteria and promotion of healing of the infected thermal injury wounds due to LC ointment were superior to those of Eksalb ointment, Azunol ointment and Mafatate (mafenide acetate) cream, and almost the same degree as that of Geben (silver sulfadiazine) cream. These effects of L. casei were nearly the same or somewhat superior compared with that of other lactobacilli, and were enhanced by the addition of gentamicin or ofloxacin.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 35
issue
Issue 1
start page
1
end page
14
date of issued
1986-03
publisher
Hiroshima University School of Medicine
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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