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ID 49779
file
creator
MASAKI, Satoshi
TAKIGAWA, Hidehiko
KUNISHO, Shoma
KIMOTO, Akiko
subject
Helicobacter suis
Helicobacter pylori
mucosa-associated lymphoid tissue (MALT) lymphoma
non-Helicobacter pylori Helicobacter (NHPH)
abstract
Objective: In patients with Helicobacter pylori-negative gastric mucosa-associated lymphoid tissue (MALT) lymphoma, eradication therapy is only effective in some cases, suggesting that infections with non-H. pylori Helicobacter (NHPH) species may also be involved. Therefore, we examined the prevalence of infection with Helicobacter suis, an NHPH, in gastric MALT lymphoma patients.
Methods: We examined the H. suis infection status of 15 patients with H. pylori-negative gastric MALT lymphoma. To examine the infection prevalence through species-specific PCR analysis, DNA was extracted from the lymphoma lesion and the background gastric mucosa. We compared the PCR products amplified from DNA extracted from different lesions.
Results: H. suis was detected in 3 of the 15 cases (20.0%), but only in the background gastric mucosa and not in the lymphoma lesion. H. suis was completely eradicated in all three cases and two of the three cases exhibited complete remission of the lymphoma.
Conclusion: These results indicated that H. suis infection may be involved in the pathogenesis of gastric MALT lymphoma. We conclude that it is desirable to use multiple biopsies, including the background mucosa, to evaluate NHPH infection in gastric MALT lymphoma patients.
description
This research was partially supported by the PUH Research Grant Program (Advanced Research A).
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 69
issue
Issue 2
start page
33
end page
37
date of issued
2020-06-30
publisher
Hiroshima University Medical Press
issn
0018-2052
2433-7668
ncid
publisher doi
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
rights
Copyright (c) 2020 Hiroshima University Medical Press
relation url
department
Graduate School of Biomedical & Health Sciences
University Medical Hospital
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