CHEMISTRY OF ANTI-HIV ACTIVE TRIMERIC PYRANONAPHTHO-QUINONE CONOCURVONE: SYNTHETIC STUDIES TOWARDS MONOMERIC TERETIFOLIONE B AND RELATED COMPOUNDS
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Pyranonaphthoquinone natural products are widely distributed in plants and microorganisms and have diverse biological activities. Angular benzochromenes are a small class of natural products isolated from Conospermum and Pentas plants. Of these, conocurvone was isolated from Conospermum as a trimeric pyranonaphthoquinone that has potent anti-HIV activity. We have focused on the total synthesis of compounds that exhibit biological activity or whose activity is enhanced upon oligomerization. This review describes the discovery and biological activities of the trimeric pyranonaphthoquinone conocurvone and related compounds, as well as our and other researchers’ synthetic studies toward monomeric pyranonaphthoquinones.
This work was partially supported by The Uehara Memorial Foundation, a Grant from Musashino Joshi-Gakuin, and JSPS KAKENHI Grant Number JP19K06975.
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The Japan Institute of Heterocyclic Chemistry
Copyright (c) 2019 The Japan Institute of Heterocyclic Chemistry
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Graduate School of Biomedical & Health Sciences
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