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ID 38136
file
creator
Sumiyoshi, Hiromichi
Oda, Noriko
Miyamori, Shinji
Kameda, Takashi
Takekura, Naoki
Takanashi, Atsushi
Tahara, Eiichi
subject
Human epidermal growth factor
DNA synthesis
Gastrointestinal mucosa
NDC
Medical sciences
abstract
Interaction between epidermal growth factor (EGF) and gastrin on DNA synthesis of the rat gastrointestinal tract was examined. Fasted male rats were divided into four groups and injected with 10 μg/kg human EGF, 300 μg/kg pentagastrin, human EGF plus pentagastrin and saline (control), respectively. The animals were sacrificed 8 or 16 hr thereafter and the incorporation of [3H]thymidine into the gastrointestinal mucosa was measured. Human EGF increased DNA synthesis of the fundus, antrum and cecum, while pentagastrin stimulated that of the fundus, duodenum, ileum and proximal colon. Synchronous administration of these peptides also stimulated DNA synthesis of the fundus, antrum and cecum. However, in the ileum and proximal colon, DNA synthesis stimulated by pentagastrin was suppressed by the administration of both agents synchronously. These data suggest that these growth factors regulate the growth of gastrointestinal tract with complex interactions.
description
This work was supported by Grant-in Aid for Cancer Research from the Ministry of Education, Science and Culture of Japan (59010074, 60010075).
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 37
issue
Issue 1
start page
1
end page
6
date of issued
1988-03
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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