このエントリーをはてなブックマークに追加
ID 38006
file
creator
Matsui, Kazuyuki
Fujioka, Yasuhiro
Kikuchi, Hirosato
Yuge, Osafumi
Fujii, Kohyu
Morio, Michio
Endo, Makoto
subject
Calcium induced calcium release (CICR)
Skinned fiber
Volatile anesthetics
NDC
Medical sciences
abstract
The effects of various volatile anesthetics on intramuscular Ca2+-related functions were studied with the skinned fiber technique in guinea pig skeletal muscles. All the volatile anesthetics tested significantly enhanced Ca2+-induced Ca2+ release (CICR) from the sarcoplasmic reticulum (SR) at clinical concentrations with negligible effects both on Ca2+ sensitivity of the contractile system and on Ca2+ uptake by the SR. A comparison was made of the enhancing effect of several volatile anesthetics on CICR at clinical concentrations. Halothane was the most potent, followed by methoxyflurane, isoflurane, enflurane, sevoflurane and diethyl ether. If CICR plays an important role in triggering MH, this order of volatile anesthetics on their enhancing effect on CICR, also corresponds to their potency in triggering MH.
description
This study was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education in Japan.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 40
issue
Issue 1
start page
9
end page
13
date of issued
1991-03
publisher
Hiroshima University Medical Press
issn
0018-2052
ncid
pubmed id
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
他の一覧



Last 12 months's access : ? times
Last 12 months's DL: ? times


This month's access: ? times
This month's DL: ? times