Growth Hormone Receptor Expression in Brain Tumors
Use this link to cite this item : https://ir.lib.hiroshima-u.ac.jp/00035004
ID | 35004 |
file | |
creator |
Sakoguchi, Tetsuhiko
Arita, Kazunori
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subject | Growth hormone
Growth hormone receptor
Brain tumor
Pituitary adenoma
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NDC |
Medical sciences
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abstract | Growth hormone (GH) is essential for quality of life in both children and adults, but it is also believed to enhance the growth of various neoplasms. However, the role of GH in the brain, particularly in brain tumors, has yet to be established. To clarify these problems from the perspective of receptor expression, we examined GH receptor (GHR) expression in brain tumors using immunohistochemistry and the correlation between GHR expression and clinical features. Surgical specimens obtained from patients with brain tumors (106 pituitary adenomas, 12 craniopharyngiomas, 13 germ cell tumors, 6 medulloblastomas, and 12 malignant gliomas) were examined immunohistochemically for GHR expression. The GHR positive rate was lower in malignant tumors than in benign tumors (59% in pituitary adenomas, 73% in craniopharyngiomas, 23% in germ cell tumors, and 0% in medulloblastomas and gliomas). GHR staining in pituitary adenomas was weaker than that in normal pituitary gland. Among the GH-producing pituitary adenomas, there was no difference in size between GHR-positive and -negative tumors. However, among the non-GH-producing adenomas, GHR-positive tumors were significantly smaller. Thus, immunohistochemical GHR expression may have, at least in part, a negative impact on tumor growth potential in brain tumors.
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journal title |
Hiroshima Journal of Medical Sciences
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volume | Volume 61
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issue | Issue 1
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start page | 1
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end page | 6
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date of issued | 2012-03
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publisher | Hiroshima University Medical Press
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issn | 0018-2052
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ncid | |
language |
eng
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nii type |
Departmental Bulletin Paper
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HU type |
Departmental Bulletin Papers
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DCMI type | text
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format | application/pdf
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text version | publisher
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rights | (c) Hiroshima University Medical Press.
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department |
Graduate School of Biomedical Science
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