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ID 26303
file
creator
Akagi, Nana
Anniko, Matti
subject
endolymphatic hydrops
lipopolysaccharide
aldosterone
mice
Ménière's disease
NDC
Medical sciences
abstract
Conclusion. A new mouse model for Ménière's disease has been developed by the treatment with both LPS and aldosterone. The induction of vestibular dysfunction in the hydropic animals model may require additional stress such as reduced inner ear blood flow, acute changes of endolymph volume and/or pressure, etc. Objective. The aim of this study is to develop a more suitable animal model, which shows more resemblance to the pathophysiological process in Ménière's disease. Materials and methods. Adult CBA/J mice were treated with intratympanic injection of LPS, intraperitoneal injection of aldosterone or injection of both LPS and aldosterone. Morphological analysis was performed in the cochlea and endolymphatic sac. Results. All experimental animals showed mild to moderate endolymphatic hydrops. The animals treated with both LPS and aldosterone showed reversible vestibular dysfunction after the intratympanic injection of epinephrine.
journal title
Acta Oto-Laryngologica
volume
Volume 128
issue
Issue 3
start page
263
end page
271
date of issued
2008
publisher
Taylor & Francis
issn
0001-6489
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2008 Taylor & Francis
relation url
department
Graduate School of Biomedical Science



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