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ID 20635
file
creator
Higashikawa, Fumiko
subject
Osteopontin
Transglutaminase 2
Integrin
Polymerization
NDC
Biology
abstract
Osteopontin is a multifunctional glycoprotein with roles in immunomodulation, inflammatory response, tissue mineralization, and tissue remodeling, which are mediated primarily through integrins. Transglutaminase 2 selectively cross-links proteins by isopeptide bonding. Osteopontin is one of the substrates of this enzyme and undergoes polymerization; however, the biological meaning of this polymerization remains unknown. Using recombinant osteopontin polymerized with purified transglutaminase 2, we examined cell adhesion, spreading, focal contact formation, and migration of SW480 or HUVE cells. All of these cellular behaviors were dramatically enhanced with polymeric osteopontin. These enhancements of cellular functions imply that polymerization might modulate physiological and pathological functions of osteopontin.
journal title
FEBS Letters
volume
Volume 581
issue
Issue 14
start page
2697
end page
2701
date of issued
2007-06-12
publisher
Elsevier Science B.V.
issn
0014-5793
ncid
publisher doi
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2007 Federation of European Biochemical Societies Published by Elsevier B.V.
relation url
department
Health Service Center



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