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ID 17698
file
creator
Okita, Riki
Saeki, Toshiaki
Takashima, Shigemitsu
Aogi, Kenjiro
Ohsumi, Shozo
subject
Breast cancer
Trastuzumab
Stereotactic radiosurgery (SRS)
Central nervous system (CNS) metastasis
NDC
Medical sciences
abstract
We report two cases of central nervous system (CNS) metastases during systemic response to trastuzumab in combination with chemotherapy for refractory breast cancer. The patients responded to trastuzumab in combination with chemotherapy. During combination treatment, the patients developed cerebellar metastases. A follow-up computed tomography scan revealed that their diseases continued to respond outside the CNS. These cases suggest that the failure of trastuzumab to cross the blood-brain barrier may compromise its overall effectiveness and raises the possibility that CNS metastasis may become clinically more significant in patients receiving antibody-based therapies, including patients responding to therapy outside the CNS. Additionally, repeated stereotactic radiosurgery as gammaknife combination therapy synchronously with systematic trastuzumab-based therapy was useful for the treatment of metastatic breast carcinoma.
journal title
Hiroshima Journal of Medical Sciences
volume
Volume 54
issue
Issue 1
start page
35
end page
38
date of issued
2005-03
publisher
Hiroshima University Medical Press
国立情報学研究所
issn
0018-2052
ncid
language
eng
nii type
Departmental Bulletin Paper
HU type
Departmental Bulletin Papers
DCMI type
text
format
application/pdf
text version
publisher
department
Graduate School of Biomedical Science
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