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ID 17221
file
creator
Ogata, Toru
Gregoire, Lucie
Goddard, Katrina AB
Skunca, Magdalena
Tromp, Gerard
Lancaster, Wayne D
Parrado, Antonio R
Lu, Qing
Shibamura, Hidenori
Sakalihasan, Natzi
Limet, Raymond
MacKean, Gerald L
Arthur, Claudette
Kuivaniemi, Helena
NDC
Medical sciences
abstract
Background: Chronic inflammation and autoimmunity likely contribute to the pathogenesis of abdominal aortic aneurysms (AAAs). The aim of this study was to investigate the role of autoimmunity in the etiology of AAAs using a genetic association study approach with HLA polymorphisms. Methods: HLA-DQA1, -DQB1, -DRB1 and -DRB3-5 alleles were determined in 387 AAA cases (180 Belgian and 207 Canadian) and 426 controls (269 Belgian and 157 Canadian) by a PCR and single-strand oligonucleotide probe hybridization assay. Results: We observed a potential association with the HLA-DQA1 locus among Belgian males (empirical p = 0.027, asymptotic p = 0.071). Specifically, there was a significant difference in the HLA-DQA1*0102 allele frequencies between AAA cases (67/322 alleles, 20.8%) and controls (44/356 alleles, 12.4%) in Belgian males (empirical p = 0.019, asymptotic p = 0.003). In haplotype analyses, marginally significant association was found between AAA and haplotype HLA-DQA1-DRB1 (p = 0.049 with global score statistics and p = 0.002 with haplotype-specific score statistics). Conclusion: This study showed potential evidence that the HLA-DQA1 locus harbors a genetic risk factor for AAAs suggesting that autoimmunity plays a role in the pathogenesis of AAAs.
journal title
BMC Medical Genetics
volume
Volume 7
start page
67
date of issued
2006-07-31
publisher
BioMed Central
issn
1471-2350
ncid
publisher doi
pubmed id
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
publisher
rights
Copyright (c) 2006 Ogata et al; licensee BioMed Central Ltd.
relation url
department
Graduate School of Biomedical Science



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