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ID 17103
file
creator
Tamura, Hiroki
Kanamoto, Takashi
Kato, Tomoko
Sasaki, Ken
Izumi, Yuishin
Mishima, Hiromu K.
subject
Alzheimer's disease (AD)
Open-angle glaucoma (OAG)
Apolipoprotein E (APOE)
Intraocular pressure (IOP)
Japanese
Prevalence
Polymorphism
NDC
Medical sciences
abstract
The clinical and genetic relationships between Alzheimer's disease (AD) and glaucoma remain obscure. The aim of this study was to determine the prevalence of open-angle glaucoma (OAG) in patients with AD and whether the apolipoprotein E (APOE) 4 allele is associated with AD, with or without OAG, in Japanese. The groups consisted of 172 patients with the diagnostic criteria of AD and 176 age-matched controls. Ophthalmic examinations were conducted, and genomic analysis was performed by PCR and digestion of products with an enzyme. OAG was found in 41 (23.8%) of the AD patients, which was a significantly (p=0.0002) higher prevalence than that in the controls (9.9%). Furthermore, there was no significant difference between intraocular pressures (IOPs) in AD patients with OAG and without OAG. The percentage of AD patients who carried an APOE ε4 allele (29.5%) was significantly (p=0.0007) higher than that of the controls (9.1%). However, the percentage of AD patients with OAG who carried an APOE ε4 allele (35.7%) was not significantly different than that of AD patients without OAG (27.7%, p=0.42). In summary, the prevalence of OAG is high in Japanese patients with AD, suggesting that common factors other than APOE may contribute to the two diseases.
journal title
Journal of the Neurological Sciences
volume
Volume 246
issue
Issue 1-2
start page
79
end page
83
date of issued
2006-07-15
publisher
Elsevier
issn
0022-510X
ncid
publisher doi
pubmed id
language
eng
nii type
Journal Article
HU type
Journal Articles
DCMI type
text
format
application/pdf
text version
author
rights
Copyright (c) 2006 Elsevier Ltd.
relation url
department
Research Institute for Radiation Biology and Medicine



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