It is an interesting open question when Dehn surgery on a knot in the 3-sphere S3 can produce a lens space (see [10, 12]). Some studies have been made for special knots; in particular, the question is completely solved for torus knots [21] and satellite knots [3, 29, 31]. It is known that there are many examples of hyperbolic knots which admit Dehn surgeries yielding lens spaces. For example, Fintushel and Stern [8] have shown that 18- and 19-surgeries on the ([minus sign]2, 3, 7)-pretzel knot give lens spaces L(18, 5) and L(19, 7), respectively. However, there seems to be no essential progress on hyperbolic knots. It might be a reason that some famous classes of hyperbolic knots, such as 2-bridge knots [26], alternating knots [5], admit no surgery yielding lens spaces.In this paper we focus on the genera of knots to treat the present condition methodically and show that there is a constraint on the order of the fundamental group of the resulting lens space obtained by Dehn surgery on a hyperbolic knot. Also, this new standpoint enables us to present a conjecture concerning such a constraint, which holds for all known examples.