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別タイトル
TIMP-1 c.T372C遺伝子多型による急性大動脈解離の予測可能性
著者
Naychov, Zheko Dimitrov
キーワード
Aortic dissection
SNP
TIMP-1
NDC
医学
抄録(英)
While single nucleotide polymorphisms (SNP) have been extensively researched in atherosclerotic aortic aneurysms, there are too few data about acute aortic dissection (AAD). The matrix metalloproteinase regulation system has shown a high biological relevance to the development of aortic aneurysms and AAD. The TIMP-1 c.T372C (rs4898, nt+434) SNP was previously associated with the onset of abdominal aortic and other aneurysms. Therefore, we chose this SNP to search for a connection with AAD and to find its place among the other risk factors. 115 patients with AAD were studied for their TIMP-1 c.T372C genotype by means of conventional restrictase analysis. To confirm the biological relevance of our findings, immunohistochemistry for TIMP-1 was performed on tissue samples from the same patients with AAD and compared with a control group of 23 autopsy cases. The TIMP-1 c.T372C showed a significant difference in allele frequency in the AAD patients compared to the general population (p < 0.0001 for both sexes). This genotype did not show any association with any other co-morbid condition, nor with age. The immunohistochemistry results also showed significantly lower TIMP-1 expression in the dissected aortas. The C allele of TIMP-1 c.T372C shows a strong association with the onset of AAD.
作成年月日
2014-11-25
言語
英語
NII資源タイプ
学位論文
広大資料タイプ
学位論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
ETD
関連情報(references)
Zheko Dimirtov Naychov, Eiso Hiyama, Naomichi Uchida, Koji Arihiro, Masataka Nagao, Shinya Takahashi, Konstantin Vassilev Delchev and Taijiro Sueda; TIMP-1 c.T372C Genetic Polymorphism as a Possible Predictor for Acute Aortic Dissection; Hiroshima J. Med. Sci. Vol.62, No.2, 31-37, June, 2013
学位記番号
甲第6245号
授与大学
広島大学(Hiroshima University)
学位名
博士(医学)
学位名の英名
Philosophy in Medical Science
学位の種類の英名
doctoral
学位授与年月日
2013-09-25
部局名
医歯薬学総合研究科