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ID 47065
本文ファイル
著者
Mori, Asako
Okamoto, Yasumasa 大学院医歯薬保健学研究科(医) 広大研究者総覧
Okada, Go 大学院医歯薬保健学研究科(医) 広大研究者総覧
Takagaki, Koki 保健管理センター 広大研究者総覧
Takamura, Masahiro 大学院医歯薬保健学研究科(医) 広大研究者総覧
Ichikawa, Naho 大学院医歯薬保健学研究科(医) 広大研究者総覧
Yamamura, Takanao
Yokoyama, Satoshi
Shiota, Syouichi
Yoshino, Atsuo 大学院医歯薬保健学研究科(医) 広大研究者総覧
Miyake, Yosie 保健管理センター 広大研究者総覧
Okamoto, Yuri 保健管理センター 広大研究者総覧
Matsumoto, Madoka
Matsumoto, Kenji
Yamawaki, Shigeto 脳・こころ・感性科学研究センター 広大研究者総覧
キーワード
Behavioural activation
intrinsic motivation
depressive disorders
imaging
functional magnetic resonance imaging
subthreshold depression
NDC
医学
抄録(英)
[Background] Behavioural activation is an efficient treatment for depression and can improve intrinsic motivation. Previous studies have revealed that the frontostriatal circuit is involved in intrinsic motivation; however, there are no data on how behavioural activation affects the frontostriatal circuit.
[Aims] We aimed to investigate behavioural activation-related changes in the frontostriatal circuit.
[Method] Fifty-nine individuals with subthreshold depression were randomly assigned to either the intervention or non-intervention group. The intervention group received five weekly behavioural activation sessions. The participants underwent functional magnetic resonance imaging scanning on two separate occasions while performing a stopwatch task based on intrinsic motivation. We investigated changes in neural activity and functional connectivity after behavioural activation.
[Results] After behavioural activation, the intervention group had increased activation and connectivity in the frontostriatal region compared with the non-intervention group. The increased activation in the right middle frontal gyrus was correlated with an improvement of subjective sensitivity to environmental rewards.
[Conclusions] Behavioural activation-related changes to the frontostriatal circuit advance our understanding of psychotherapy-induced improvements in the neural basis of intrinsic motivation.
[Declaration of interest] None.
内容記述
This work was supported by a Grant-in-Aid for Scientific Research on Innovative Areas from Japan Society for the Promotion of Science, JSPS (grants 16H06395 and 16H06399), and grant 23118004 from the Ministry of Education, Culture, Sports, Science and Technology, Japan. This work was partially supported by the programme for Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) by Japan Agency for Medical Research and Development, AMED (grant 15dm0207012h0002) and Integrated Research on Depression, Dementia and Development Disorders by AMED (grant 16dm0107093h0001).
The funders had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation or review of the manuscript or decision to submit the manuscript for publication.
掲載誌名
BJPsych Open
4巻
5号
開始ページ
317
終了ページ
323
出版年月日
2018-08-02
出版者
Cambridge University Press
ISSN
2056-4724
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
COPYRIGHT © The Royal College of Psychiatrists 2018 This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.
関連情報URL
部局名
医歯薬学総合研究科
保健管理センター
病院
その他