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ID 37859
本文ファイル
著者
Imamura, Yuji
Yokoyama, Takashi
Takesue, Yoshio
Kodama, Takashi
Matsuura, Yuichiro
キーワード
PMN
Mac-1
G-CSF
Superoxide
Esophagectomy
NDC
医学
抄録(英)
The aim of this study was to evaluate the characteristics of the polymorphonuclear leukocyte (PMN) function after surgical stress. We investigated Mac-1 expression and superoxide generation by peripheral PMNs and serum granulocyte-colony stimulating factor (G-CSF) concentrations in 15 patients who underwent either gastrectomy (n=8) or esophagectomy (n=7). The serum G-CSF rapidly increased within 24 hours after operation. The maximum levels of serum G-CSF in the cases of esophagectomy were about 5-8 fold those of gastrectomy, although the increases in PMN counts within 24 hours of esophagectomy were lower than those after gastrectomy. Mac-1 expression and superoxide generation by PMN s after gastrectomy increased significantly, in parallel with increases in the PMN counts and serum G-CSF. After esophagectomy, Mac-1 expression on peripheral PMN s remained elevated through the 7th day after operation, while superoxide generation by PMN s in response to PMA declined to below preoperative levels after the 3rd day. These results suggest that, after major surgery such as esophagectomy, there is a discrepancy between Mac-1 expression and superoxide generation by the peripheral PMN despite a high level of serum G-CSF.
掲載誌名
Hiroshima Journal of Medical Sciences
44巻
2号
開始ページ
39
終了ページ
46
出版年月日
1995-06
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
病院
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