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ID 38398
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別タイトル
ラットにおける実験的大腸腫瘍の研究: 第二報 大腸粘膜の細胞動態と大腸腫瘍発生の関係について
著者
Naito, Yukiko
キーワード
Colon tumor
DMH
Labeling index
Rat
NDC
医学
抄録(英)
1, 2-Dimethylhydrazine (DMH) was administered to a total of 131 Wister Furth substrain (WF/O) rats 20 times weekly at a dose of 20 mg/kg body weight. The tumors were more predominant in the ascending colon (64/148) than in the descending colon (13/148). Examination of the apparently normal colon after the 20th injection of DMH revealed that both the ascending (P<0.01) and descending colon epithelia (P<0.25) had a higher lebeling index than that of the control epithelia.

Twelve rats which were given a single injection of DMH at a dose of 60 mg/kg of body weight were examined to observe the acute changes in the colon mucosa. This treatment induced a greater injurious effect on the ascending colon than on the descending colon with regard to crypt height and 3H-thymidine labeling index in the nucleus. Recovery from the damage was slower in the ascending colon than in the descenting colon. High iron diamine-Alcian blue staining of the colon epithelia disclosed that sulphomucin was decreased, while sialomucin was increased in the recovery stage m both the ascending and descending colon.

These data indicate that the susceptibility of the colon to the carcinogenic effect of DMH differs by site and that the degree of cellular damage and repair by a single injection of DMH reflects the cell kinetics following a prolonged DMH treatment and ultimate tumor yield.
掲載誌名
Hiroshima Journal of Medical Sciences
31巻
1号
開始ページ
51
終了ページ
61
出版年月日
1982-03-10
出版者
Hiroshima University School of Medicine
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
原爆放射線医科学研究所
医歯薬学総合研究科
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