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ID 38112
本文ファイル
著者
Roy, Bidyut
Watanabe, Hiromitsu
Ito, Akihiro
キーワード
Rat
Methylnitrosourea
Cataract
Aggregation of βH-crystallin
NDC
医学
抄録(英)
Cataracts were observed in female F344 rats who intravenously received methylnitrosourea (MNU), a potent carcinogen for multiple organs, in one dose of 50 mg/kg body weight. Induction of cataract 40 weeks after MNU treatment was 41 % whereas no cataract was observed in control rats. The aggregation of βH-crystallin fraction by MNU was studied in vitro. HPLC pattern ofβH-crystallin changed when lens protein was incubated for 24 hrs with MNU. HPLC patterns indicated that MNU induced high molecular weight aggregates ofβH-crystallin. This study conveys some indication about the direct interaction of MNU with lens protein in cataract formation.
内容記述
This work was supported in part by Grant-in-Aid for Cancer Research from the Ministry of Education, Science and Culture, Japan.
掲載誌名
Hiroshima Journal of Medical Sciences
38巻
3号
開始ページ
95
終了ページ
98
出版年月日
1989-09
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
原爆放射線医科学研究所
医歯薬学総合研究科
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