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ID 37932
本文ファイル
著者
Shakil, Fouzia A.
Kuramoto, Atsushi
Yamakido, Michio
Nishimoto, Yukio
Kamada, Nanao
キーワード
Mustard gas
Chromosome abnormality
Sister chromatid exchange
Chronic myelocytic leukemia
NDC
医学
抄録(英)
A high incidence of cancer of the respiratory tract has been reported among former workers in a poison gas manufacturing plant which operated on Ohkunojima from 1927 to 1945. This report provides evidence of a high incidence of chromosome abnormality and sister chromatid exchange (SCE) rate among the former workers, as well as cytogenetic changes in two patients among the former workers with chronic myelocytic leukemia (CML). A chromosome study of seven former workers with chronic bronchitis revealed a stable type of aberration, the average abnormality being 10.9 ± 4.4 percent, which is equivalent to those of atomic bomb survivors exposed at 1.2 km from the hypocenter. The SCE rate observed in 16 former workers ranged from 4.9 ± 2.1 to 17.8 ± 3.9, which was significantly higher than in the control group (p<0.03). One of the CML patients showed an extremely high percentage of missing Y chromosomes along with t(9;22) translocation which is a specific chromosome aberration for the disease. Furthermore, the patient had almost a 3 times higher SCE rate compared to the control group and a high incidence of chromosome abnormality (12.1 %) of the peripheral lymphocytes. These results suggest that the development of leukemia in this patient was strongly related to poison gas exposure.
内容記述
This work was supported in part by grants-in-aid from the Ministry of Education, Science and Culture and from the Japan Public Health Association's A-Bomb Survivors Joint Research Team supported by FY 1992 Health and Welfare Ministry A-Bomb Disease Investigation and Research Entrustment Fund (Shigematsu Collaborative Study Group).
掲載誌名
Hiroshima Journal of Medical Sciences
42巻
4号
開始ページ
159
終了ページ
165
出版年月日
1993-12
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
原爆放射線医科学研究所
医歯薬学総合研究科
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