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ID 37930
本文ファイル
著者
Shakil, Abdus
Hirabayashi, Naoki
Toge, Tetsuya
キーワード
Circadian rhythm
Chemotherapy
Anticancer agents
Toxicity
Dosing time
NDC
医学
抄録(英)
Circadian variations of organ specific and lethal toxicities were investigated in fem ale C3H mice following intraperitoneal injection(s) of 5-fluorouracil (5-FU) and/or cis-platinum (CDDP) with different doses at one of the four equidistant time points, viz., 3, 9, 15 and 21 HALO (Hours After Light On). Lethality, peripheral WBC count, spleen size, femoral bone marrow cell population and changes in body weight were analyzed. A single injection of 5-FU (300 mg/kg) showed 45% mortality with 3 HALO and 15% with 9 HALO treatment (p<0.05); that with CDDP (16 mg/kg) was 80% in 3 HALO and 10% in 9 HALO group (p<0.01). Peripheral WBC count on the 4th post-treatment day showed that drug induced leukopenia was less severe with 15 HALO dosing compared to the other HALO points (p<0.01). The reduction in spleen size following treatment was maximum in 3 HALO treated group with both drugs (p<0.01). The combination therapy of these two drugs also showed circadian variation of toxicity. The results suggest that the toxic effects of chemotherapy are dosing time dependent.
掲載誌名
Hiroshima Journal of Medical Sciences
42巻
4号
開始ページ
147
終了ページ
154
出版年月日
1993-12
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
原爆放射線医科学研究所
医歯薬学総合研究科
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