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ID 38410
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別タイトル
ラットにおける実験的大腸腫瘍の研究 : 第一報 1,2-ジメチルヒドラジン誘発大腸腫瘍のラット系統差について
著者
Naito, Yukiko
NDC
医学
抄録(英)
Susceptibility to 1, 2-dimethylhydrazine (DMH) was comparatively studied using two rats strains, Wistar-Furth substrain (WF/O) rats derived from the family with a high incidence of spontaneous colon tumor, and Long-Evans (LE) rats. Ten-week-old rats of both sexes were injected with DMH (20 mg/kg body weight) weekly for 20 weeks, and sacrificed at the 10th, 15th, 20th, and 25th week after the last injection. LE rats developed colon tumors more frequently in terms of crude incidence (21/21) (p<0.01) and the number of tumors per rat (6.1) (p<0.05) than those (17/25, 2.5) in WF/O rats. The predilection site of induced tumors was the descending colon in LE rats (59/128), in which adenomas were prevailing, where only a small number of tumors were found in WF/O rats (8/42). In both strains ascending colon was far more crowded with poorly differentiated adenocarcinoma than other sites of the colon (8/19, 14/34). It is likely that a resistant rat strain (WF/O) for DMH carcinogenesis has emerged from a parent rat strain prone to develop colonic tumors spontaneously.
掲載誌名
Hiroshima Journal of Medical Sciences
30巻
4号
開始ページ
355
出版年月日
1981-12-10
出版者
Hiroshima University School of Medicine
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
原爆放射線医科学研究所
医歯薬学総合研究科
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