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ID 38364
本文ファイル
別タイトル
ニトロフラントインの経口投与によるマウスでの発癌性について
著者
Ito, Akihiro
Naito, Masashi
Naito, Yukiko
Watanabe, Hiromitsu
キーワード
Tumorigenicity
N-(5-Nitro-2-furfurylidene)-1-aminohydantoin
Mouse
NDC
医学
抄録(英)
The carcinogenicity of N-(5-Nitro-2-furfurylidene)-1-aminohydan to in (nitrofurantoin, NF-153) was examined in (C57BL/6N×DBA/2N)F1 (BDF1) mice. Three hundred of mice were divided into three groups, each group consisting about 50 male and 50 female mice. Nitrofurantoin was given in powdered diet at dose levels of 0.3, 0.075, or 0 % to the respestive group of mice. The overall incidence of tumors in male and female mice was as follows: 0.3% NF group, 7.7 and 25.9%; 0.075% NF group, 1.9 and 16.7 %; in the control group, 22.6 and 29.6 %, respectively. In the male, the total incidence of tumors in two experimental groups and that of hepatic adenoma in 0.3% NF group was significantly decreased from that of control by p<0.05 and p<0.05, respectively. There was no significant difference in the female. The results in the present study conclude that nitrofurantoin is not carcinogenic in BDF1 mice.
内容記述
This investigation was supported by a Grant-in-Aid for Cancer Research from the Ministry of Health and Welfare of Japan.
掲載誌名
Hiroshima Journal of Medical Sciences
32巻
1号
開始ページ
99
終了ページ
102
出版年月日
1983-03
出版者
Hiroshima University School of Medicine
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
原爆放射線医科学研究所
医歯薬学総合研究科
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