このエントリーをはてなブックマークに追加
ID 38323
本文ファイル
別タイトル
Wistar/Furth 亜系ラットに認められた盲腸部異型上皮について
著者
Naito, Masashi
Naito, Yukiko
Watanabe, Hiromitsu
Ito, Akihiro
キーワード
Caecal dysplasia
Spontaneous colon tumor
Rats
NDC
医学
抄録(英)
Offspring of spontaneous colon tumor prone rats (WF/O) bred in our laboratory developed tumors in a very low incidence (less than 0.2 %), but about half of these rats had dysplastic epithelium with frequent erosion in the caecum. In nine animals (4.4%) submucosal glands of the caecum were observed. These dysplasia accompanied inflammatory cell reactions and regional lymph nodes were enlarged and packed with many plasma cells. Hybrid of WF/O rats and other inbred Long-Evans strain (LE) rats, having no dysplastic lesion of the caecum, had caecal dysplasia in a low incidence (10%). These data suggest that genetic factor(s) play an important role in the occurrence of caecal dysplasia in WF/O rats. These changes may be a precondition to the spontaneous occurrence of tumors in the proximal portion of the ascending colon with the aid of promoting factor(s).
掲載誌名
Hiroshima Journal of Medical Sciences
32巻
3号
開始ページ
295
終了ページ
299
出版年月日
1983-09
出版者
Hiroshima University School of Medicine
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
原爆放射線医科学研究所
医歯薬学総合研究科
他の一覧