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ID 38178
本文ファイル
別タイトル
トロトラスト症患者と原爆被爆者の骨髄細胞、リンパ球にみられた血球小核と染色体異常
著者
Tanaka, Kimio
Izumi, Takaki
Ohkita, Takeshi
Kamada, Nanao
キーワード
Micronucleus
Chromosome aberration
Atomic bomb survivors
Thorotrast patients
NDC
医学
抄録(英)
As two cytogenetic parameters of radiation exposure, the frequency of micronucleus in erythroblasts, lymphocytes and red cells (Howell-Jolly body) as well as chromosome aberrations in bone marrow cells and in lymphocytes were studied in 24 thorotrast patients and in 32 atomic bomb (A-bomb) survivors who were exposed within one kilometer from the Hiroshima hypocenter. The incidence of both micronucleus and chromosome aberrations in these two exposed groups were significantly higher than that in non-exposed controls. So that these two parameters are useful guide for evaluating the residual effects of radiation, especially on hematopoietic cells. Because of its simple procedures, micronucleus test is also helpful as screening for prediction of chromosome aberrations. The characteristics of lymphocyte chromosome aberrations differed considerably between thorotrast patients and A-bomb survivors; the incidence of unstable type aberrations and intracellular complexity of chromosome aberrations were much higher in the former group. The incidence of micronucleus in erythroblasts and lymphocytes was also higher in thorotrast patients. Such differences are attributable to the differences in the radiation quality (α-ray or γ-ray + neutron) and in the mode of exposure (persistent or single) of these two groups.
内容記述
This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Health and Welfare and the Ministry of Education, Science and Culture.
掲載誌名
Hiroshima Journal of Medical Sciences
33巻
1号
開始ページ
101
終了ページ
111
出版年月日
1984-03
出版者
Hiroshima University School of Medicine
ISSN
0018-2052
NCID
PubMedID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
原爆放射線医科学研究所
医歯薬学総合研究科
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