このエントリーをはてなブックマークに追加
ID 37894
本文ファイル
著者
Wada, Seishi
Murakami, Hironobu
Kajihara, Hiroki
Matsuura, Yuichiro
キーワード
Xeno discordant transplantation
Hyperacute rejection
Artificial blood
Blood exchange
NDC
医学
抄録(英)
The aim of this study was to assess the effectiveness of pregraft immunomodulatory artificial blood exchange (IABX) in a guinea pig-to-rat xeno discordant heart transplantation, using an artificial blood (FC43 emulsion: The Green Cross, Japan) in exchange for a large volume of whole blood to remove humoral immune factors en bloc from the recipient rat. In the rats treated with IABX, rhythmic beating of the grafted heart was maintained for 2 hr, whereas the untreated heart beat lasted for only 15.2 ± 5.2 min (n=6). In the graft hearts treated with IABX, no pathologic changes such as multiple coronary thromboses due to hyperacute rejection (HAR) were observed. Humoral immune factors (natural-IgM titer, ACH50 and CH50 complement activities, platelet count, prothrombin time (PT), activated partial thromboplastin time (APTT) and fibrinogen serum concentration), which are thought to contribute to HAR, decreased significantly following the IABX treatment.  

We conclude that IABX is an efficient method for prolonging the survival time of guinea pig heart xenografts by inhibiting thrombus formation in the xeno-graft heart. It was confirmed that IABX could remove recipient humoral immune factors en bloc.
内容記述
This study was supported by The Green Cross Co.,Ltd.
掲載誌名
Hiroshima Journal of Medical Sciences
43巻
4号
開始ページ
153
終了ページ
161
出版年月日
1994-12
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
保健学研究科
他の一覧