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ID 37822
本文ファイル
著者
Kohata, Shuji
Ninomiya, Isio
Shinizu, Junichi
Furukawa, Kazuto
Matsuura, Yuichiro
キーワード
Renal nerve activity
Acute arterial bleeding
Aging
NDC
医学
抄録(英)
We compared the change in renal sympathetic nerve activity (RNA) during hemorrhage in young and old rats. Young (10 weeks) and old (80 weeks) male Wistar rats were anesthetized, and RNA together with arterial pressure (AP) and heart rate (HR) were measured under spontaneous respiration. Acute arterial bleeding, lm1Jl00g body weight, was carried out to induce hypotension and hypovolemia. With bleeding, mean AP (MAP) decreased from 110 ± 12 to 23 ± 11mmHg (mean ± SEM) and from 93 ± 15 to 15 ± 6mmHg in young and old rats, respectively. The difference in the change of MAP between the young and old rats was not significant. With bleeding, mean RNA increased by 46 ± 21 % and 20 ± 16% in young and old rats, respectively. The increase in mean RNA of the old rats was significantly lower than that of the young rats. We estimated the gain of the barocepter-renal sympathetic nervous system by using the formula ∆RNA/RNA/∆MAP/MAP. The gain was 0.61 ± 0.34 and 0.23 ± 0.18 in young and old rats, respectively. The difference in the gain was statistically significant (p<0.05). We concluded that the gain of baroceptor-sympathetic nerve system in acute arterial hemorrhage is attenuated with aging.
掲載誌名
Hiroshima Journal of Medical Sciences
46巻
3号
開始ページ
87
終了ページ
92
出版年月日
1997-09
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
保健学研究科
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