Lymphocyte Subpopulations in Peripheral Blood and the Spleen from Gastric Cancer Patients
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Lymphocyte subpopulations in peripheral blood and the spleen from gastric cancer patients were identified by either single or two color analysis with fluorescence activated cell sorter-IV (FACS-IV) using monoclonal antibodies. The absolute and percentages of CD3+ (mature T) cells and CD4 + (helper/inducer T) cells in peripheral blood from the advanced cancer patients were significantly lower than those from normal healthy controls. In peripheral blood, a significant decrease of CD4 + cells was due to the decrease of CD4 + CD45RA + (suppressor inducer T) cells, while CDS+ CD11b+ (suppressor T) cells tended to increase with progress of the disease. CD4+ CD45RA + cells located more predominantly in peripheral blood and spleen than in the splenic vein, while CDS+ CD11b+ cells were more predominant in the splenic vein.
Hiroshima Journal of Medical Sciences
Hiroshima University Medical Press