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ID 31592
本文ファイル
著者
Kominami, Yoko
Gon, Rina
Hayashi, Masaomi
Nishiki, Masayo
Sasaki, Atsushi
Shiraishi, Miho
Ueda, Shinobu
Ochiya, Takahiro
キーワード
Transplantation
Hetero-tissues
Duodenum
F344 GFP Rats
NDC
医学
抄録(英)
The mechanisms regulating stem cell differentiation and self-renewal are largely unknown. Our ultimate goal is to be able to regulate somatic stem cell differentiation and proliferation, In the present study the ability of trans-differentiation was studied when different normal tissue types were transplanted into the duodenum in rats. Pieces of ear (skin), bladder, trachea, diaphragm, pyloric gland. and forestomach from 8-week old GFP-F344 rats were transplanted into the duodenum of F344 rats. Goblet cells with alcian-blue PAS positive mucin and brash border with alkaline phosphatase (ALP) activity appeared in tissues implanted into the duodenum. In addition, GFP-positive duodenal mucosa was observed in all cases by immunohistochemical staining. Moreover, the GFP-positive cells were found to carry the GFP transgene by PCR analysis. indicating that the bladder, trachea. ear (skin), diaphragm, pyloric gland, and farestomach tissues showed a multipotential ability for differentiation. These results indicated that stem cells within tissues have a multipotential ability, trans-differentiating into different organs when transplanted into different environments.
掲載誌名
Hiroshima Journal of Medical Sciences
60巻
1号
開始ページ
1
終了ページ
6
出版年月日
2011-03
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
原爆放射線医科学研究所
自然科学研究支援開発センター
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