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ID 46735
本文ファイル
著者
Yoshida, Kengo
Ohishi, Waka
Nakashima, Eiji
Fujiwara, Saeko
Akahoshi, Masazumi
Kasagi, Fumiyoshi
Hakoda, Masayuki
Kyoizumi, Seishi
Nakachi, Kei
Hayashi, Tomonori
Kusunoki, Yoichiro
キーワード
Cohort study
hepatitis C virus
liver fibrosis
lymphocyte subset
NDC
医学
抄録(英)
This study aims to deepen understanding of lymphocyte phenotypes related to the course of hepatitis C virus (HCV) infection and progression of liver fibrosis, in a cohort of atomic-bomb survivors. The study subjects comprise three groups: 162 HCV persistently infected, 145 spontaneously cleared, and 3511 uninfected individuals. We found increased percentages of peripheral blood TH1 and total CD8 T cells and decreased percentages of NK cells in the HCV persistence group, compared with the other two groups, after adjustment for age, gender, and radiation exposure dose. Subsequently, we found that increased TH1 cell percentages in the HCV persistence group were significantly associated with an accelerated time-course reduction in platelet counts―accelerated progression of liver fibrosis―while TC1 and NK cell percentages were inversely associated with the progression. This study suggests that TH1 immunity is enhanced by persistent HCV infection, and that percentages of peripheral TH1, TC1, and NK cells may help predict progression of liver fibrosis.
内容記述
This research was based on RERF Research Protocols 3-09, 4-02, 2-00, 9-92, and was supported in part by the U.S. National Institute of Allergy and Infectious Diseases (NIAID Contract HHSN272200900059C).
掲載誌名
Human Immunology
72巻
10号
開始ページ
821
終了ページ
826
出版年月日
2011-10
出版者
American Society for Histocompatibility and Immunogenetics
ISSN
0198-8859
1879-1166
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
関連情報URL
部局名
医歯薬学総合研究科