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ID 47061
本文ファイル
著者
Ishida, Keishi
Saiki, Takashi
Umeda, Kanae
Miyara, Masatsugu
Sanoh, Seigo 大学院医歯薬保健学研究科(薬) 広大研究者総覧
Ohta, Shigeru 大学院医歯薬保健学研究科(薬)
Kotake, Yaichiro 大学院医歯薬保健学研究科(薬) 広大研究者総覧
キーワード
tributyltin
glutamate receptor 2
developmental neurotoxicity
NDC
医学
抄録(英)
Tributyltin (TBT), a common environmental contaminant, is widely used as an antifouling agent in paint. We previously reported that exposure of primary cortical neurons to TBT in vitro decreased the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit glutamate receptor 2 (GluR2) expression and subsequently increased neuronal vulnerability to glutamate. Therefore, to identify whether GluR2 expression also decreases after TBT exposure in vivo, we evaluated the changes in GluR2 expression in the mouse brain after prenatal or postnatal exposure to 10 and 25 ppm TBT through pellet diets. Although the mean feed intake and body weight did not decrease in TBT-exposed mice compared with that in control mice, GluR2 expression in the cerebral cortex and hippocampus decreased after TBT exposure during the prenatal period. These results indicate that a decrease in neuronal GluR2 may be involved in TBT-induced neurotoxicity, especially during the fetal period.
内容記述
This study was supported by JSPS KAKENHI (B) Grant Numbers 23310047 (to Y.K.), 15H02826 (to Y.K.), and a Grant-in-Aid for JSPS Fellows Number 14J06534 (to K.I.).
掲載誌名
Biological and Pharmaceutical Bulletin
40巻
7号
開始ページ
1121
終了ページ
1124
出版年月日
2017-07-01
出版者
The Pharmaceutical Society of Japan
ISSN
0918-6158
1347-5215
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
© 2017 The Pharmaceutical Society of Japan
関連情報URL
部局名
医歯薬保健学研究科