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ID 47052
本文ファイル
著者
Takahashi, Tomoko
Niinuma, Yoshifumi
Nomura, Yasuyuki
キーワード
manganese superoxide dismutase (MnSOD)
endoplasmic reticulum (ER) stress
IRE1
nuclear factor (NF)-κB
AP-1
NDC
医学
抄録(英)
Manganese superoxide dismutase (MnSOD) is an antioxidative enzyme that scavenges superoxide radicals and is localized in the mitochondrial matrix. MnSOD is induced by a variety of stimuli through nuclear factor (NF)-κB and AP-1 activation. We investigated the expression of MnSOD in HeLa cells exposed to various agents interfering with endoplasmic reticulum (ER) functions. All agents caused an increase in the mRNA and protein levels of MnSOD. Although ER stress-responsive genes often are up-regulated by ATF6, IRE1 and XBP1, which are ER stress-related transcription factors/transducers, the overexpression of neither molecule affected the levels of MnSOD mRNA and protein. Furthermore, we showed that ER stress reagents induced NF-κB and AP-1 activation that were inhibited by a dominant-negative IRE1 mutant. We finally demonstrated that ER stress-induced MnSOD expression was reduced by the IRE1 mutant. These results suggest that the MnSOD expression is controlled by ER stress through IRE1-mediated NF-κB and AP-1 activation.
内容記述
This study was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technalogy, Japan.
掲載誌名
Biological and Pharmaceutical Bulletin
27巻
8号
開始ページ
1202
終了ページ
1206
出版年月日
2004-08
出版者
The Pharmaceutical Society of Japan
ISSN
0918-6158
1347-5215
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
© 2004 The Pharmaceutical Society of Japan
関連情報URL
部局名
医歯薬保健学研究科