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ID 35023
本文ファイル
著者
Jitsuiki, Hiroaki
Izumitani, Satoru
Suzuki, Katsuji
Tanaka, Teruaki
Inoue, Takeshi
Koyama, Tsukasa
Wada, Ken
Masaoka, Yukari
Sasaki, Takanobu
Yoshimura, Reiji
Nakamura, Jun
Sumitani, Satsuki
Ohmori, Tetsuro
キーワード
Valproate
Serum valproate level
Bipolar disorder
Maintenance therapy
NDC
医学
抄録(英)
The appropriate therapeutic serum valproate level in maintenance therapy for bipolar disorder is not well known. We studied the serum valproate levels in seventeen bipolar I and twenty-four bipolar II disorder outpatients who had been treated with stable doses of valproate successfully for at least 12 months as prophylactic therapy. The trough serum valproate levels were 52.2 ± 20.4 μg/ml in bipolar I, and 41.0 ± 18.3 μg/ml in bipolar II disorder patients, respectively. A greater trend towards a higher trough level (p=0.07) was indicated in the bipolar I disorder group. We speculate that these valproate levels may be an approximation to the appropriate valproate levels in maintenance therapy and that there may be a correlation between the level of valproate required for stabilization and the subtype of the bipolar disorder. However, when interpreting these findings, certain limitations to this study?need to be taken into account as follows. The sample size was small. We could not look at a group on valproate that had relapsed and a group that had dropped out of maintenance therapy. Further studies are needed.
掲載誌名
Hiroshima Journal of Medical Sciences
62巻
1号
開始ページ
7
終了ページ
12
出版年月日
2013-03
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
(c) Hiroshima University Medical Press.
部局名
医歯薬保健学研究科
病院
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