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ID 45391
本文ファイル
著者
Abou Elazab, Mohamed Fahmy 大学院生物圏科学研究科
Horiuchi, Hiroyuki 大学院生物圏科学研究科 広大研究者総覧
Furusawa, Shuichi 大学院生物圏科学研究科 広大研究者総覧
キーワード
chick
maternal antibody
non-specific
suppression
T-cell
NDC
畜産業
抄録(英)
Specific immune suppression in newly hatched chicks induced by specific maternal antibodies has been reported. Laying hens were immunized with dinitrophenyl-keyhole limpet hemocyanin (DNP-KLH). Purified maternal anti-DNP and non-specific immunoglobulin (Ig) Y antibodies were transferred by yolk sac inoculation to newly hatched chicks, and then, they were immunized with an optimum immunogenic dose of DNP-KLH at 1 and 4 weeks of age. Concentrations of anti-DNP antibodies in serum samples of these chicks were measured by using Enzyme-linked immunosorbent assay (ELISA). Proportions of T-cell subsets in peripheral blood of these chicks were also measured by flow cytometric analysis at 5 weeks of age (one week after the second immunization). Suppression of anti-DNP antibody response and down-regulation of CD3+CD4+ cells were observed in the chicks received high dose of maternal anti-DNP antibodies and immunized with DNP-KLH. On the other hand, normal anti-DNP antibody response and normal proportion of CD3+CD4+ cells were observed in the chicks received high dose of non-specific IgY antibodies and immunized with DNP-KLH. Furthermore, when chicks received high dose of maternal anti-DNP antibodies and immunized with DNP-KLH at 1 and 4 weeks of age and then with rabbit serum albumin (RSA) at 5 and 8 weeks of age, their primary anti-RSA response was also significantly suppressed. We indicate here that specific maternal antibodies can affect both B and T cell responses and induce non-specific suppression against different antigens. However, this non-specific suppression does not continue for a long time.
内容記述
This study was supported by research project for improving food safety and animal health of the Ministry of Agriculture, Forestry and Fisheries of Japan.
掲載誌名
Journal of Veterinary Medical Science
77巻
11号
開始ページ
1363
終了ページ
1369
出版年月日
2015-06-06
出版者
The Japanese Society of Veterinary Science
公益社団法人日本獣医学会
ISSN
1347-7439
0916-7250
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
Copyright (c) 2015 The Japanese Society of Veterinary Science
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License <http://creativecommons.org/licenses/by-nc-nd/3.0/>.
関連情報URL
部局名
生物圏科学研究科