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ID 46209
本文ファイル
著者
Ikeda, Atsushi 大学院工学研究科 広大研究者総覧
Satake, Shuhei
Mae, Tomoya
Ueda, Masafumi 大学院工学研究院
Sugikawa, Kouta 大学院工学研究科 広大研究者総覧
Shigeto, Hajime
Funabashi, Hisakage 大学院先端物質科学研究科 広大研究者総覧
Kuroda, Akio 大学院先端物質科学研究科 広大研究者総覧
キーワード
porphyrin
cyclodextrin
photodynamic therapy
photosensitizer
NDC
化学
抄録(英)
Water-soluble cyclodextrin (CyD)-complexed with porphyrin derivatives with different substituents in the mesopositions showed different photodynamic activities toward cancer cells under illumination at wavelengths over 600 nm, the most suitable wavelengths for photodynamic therapy (PDT). In particular, aniline- and phenol-substituted derivatives had high photodynamic activity because of the efficient intracellular uptake of the complexes by tumor cells. These complexes showed greater photodynamic activity than photofrin, currently the main drug in clinical use as a photosensitizer. These results represent a significant step towards the optimization of porphyrin derivatives as photosensitizers.
内容記述
Supporting Information is available free of charge on the ACS Publications website.
Experimental procedures and UV-vis absorption and NMR spectra (PDF).
This work was supported by JSPS KAKENHI Grant-in-Aid for Scientific Research (B) (Grant No. JP16H04133) and Grant-in-Aid for Challenging Exploratory Research (Grant No. JP16K13982) and the Electric Technology Research Foundation of Chugoku.
掲載誌名
ACS Medicinal Chemistry Letters
8巻
5号
開始ページ
555
終了ページ
559
出版年月日
2017-05-11
出版者
American Chemical Society
ISSN
1948-5875
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2017 American Chemical Society
This document is the Accepted Manuscript version of a Published Work that appeared in final form in 'ACS Medicinal Chemistry Letters', copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsmedchemlett.7b00098.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
部局名
工学研究科
先端物質科学研究科