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ID 48177
本文ファイル
著者
Nishinaga, Masanori
Onizuka, Yuh-ichi
Hanafusa, Takahiro
Nomiyama, Kei-ichi
Watanabe, Daisuke
Kinashi, Toshifumi
Murashige, Toshiaki
Kunishi, Munehiro
Hori-e, Ryota
Hayashida, Yasufumi
Yamashita, Ichirou 自然科学研究支援開発センター
キーワード
maternal estrogen
estrogen receptor
retinoic acid
hindbrain
anterior-posterior axis
vasculogenesis
medakafish
抄録(英)
Fertilized eggs of lower vertebrates contain substantial amounts of steroidal hormones such as estrogen transferred from mother during oogenesis. However, molecular roles for maternal estrogen in the early embryonic development are largely unknown. Here we show that maternal estrogen and estrogen receptor-α modulate retinoic acid (RA) metabolism and RA-responsive gene expression in medaka embryos. Treatments with excess estradiol, an anti-estrogen (tamoxifen), overexpression or knockdown of estrogen receptor-α (ERα) resulted in misregulation of RA-related gene expression such as raldh2 (retinalaldehyde dehydrogenase), cyp26a1 (RA hydroxylase), fgf8 (fibroblast growth factor), rarα (RA receptor-α), and ahr1 (aryl hydrocarbon receptor). We propose that maternal estrogen/ERα plays a critical role in the feedback control of in vivo level of RA and that it also activates RA signaling for the development of hindbrain and vasculatures. This is the first report demonstrating that maternal estrogen supports successful embryonic development by controlling RA metabolism and signaling in early vertebrate embryos.
内容記述
Supported by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
開始ページ
1
終了ページ
87
作成年月日
2019-09-18
言語
英語
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その他
広大資料タイプ
その他
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フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2019 by Authors
部局名
自然科学研究支援開発センター
備考
未発表原稿