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ID 47694
本文ファイル
著者
Sada, Naotaka
Hanafusa, Takahiro
Onizuka, Yuichi
Hayashida, Yasufumi
Kageyama, Shota
Yamashita, Ichiro 自然科学研究支援開発センター
キーワード
arly hydrocarbon receptor
common cardinal vein
retinoic acid
retinoic acid receptor
medakafish
抄録(英)
Retinoic acid (RA) has been shown to have a role in vascular formation, but how it affects is not fully understood. Previously, we reported that RA and its nuclear receptor (RAR) is required for transcription of ahr1 encoding an aryl hydrocarbon receptor (AHR), and that pharmacological modulation of RA, RAR, and AHR impairs the formation of common cardinal veins (CCVs) on the yolk of medakafish embryos. Here, to delineate a role for ahr1 in the vascular formation, we used an antisense-ahr1 mRNA to suppress ahr1. Following the development of vegfr1-expressing angioblast cells, we show that the antisense-ahr1 greatly inhibited the accumulation of angioblasts at the prospective branchial arch (PBA) where CCVs begin to develop on the yolk and the following CCV formation, demonstrating for the first time the essential role of ahr1 in the embryonic vascular formation of vertebrates. We also show that rarα and ahr1 mRNAs are co-expressed at PBA, suggesting a possible role of the specific expression.
内容記述
This work was supported in part by a grant from the Ministry of Education, Science, Sports and Culture of Japan.
開始ページ
1
終了ページ
26
作成年月日
2019-06-07
言語
英語
NII資源タイプ
その他
広大資料タイプ
その他
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2019 by Authors
部局名
自然科学研究支援開発センター
備考
未発表原稿