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ID 35006
本文ファイル
著者
Imai, Keisuke
Munehisa, Yumiko
Yoshikuni, Yoshiko
Morita, Tadayuki
Nomura, Hiroaki
Mimaki, Yuichi
キーワード
Theophylline
Children
Pyrexia
Clearance
NDC
医学
抄録(英)
Fifty hospitalized children with asthmatic bronchitis and bronchial asthma were treated with a continuous intravenous drip infusion of aminophylline. To investigate the pharmacokinetics of theophylline in the presence of pyrexia, patients were divided into two groups based on body temperature: a pyrexia group (≥ 38°C) and a non-pyrexia group (< 38°C). Theophylline clearance was 0.064 ± 0.017 liters/kg/hr in the non-pyrexia group and 0.049 ± 0.010 liters/kg/hr in the pyrexia group. Theophylline clearance in the non-pyrexia and pyrexia groups was 0.044 ± 0.007 liters/kg/hr and 0.030 ± 0.009 liters/kg/hr (≤ 6 months), 0.071 ± 0.011 liters/kg/hr and 0.047 ± 0.008 liters/kg/hr (6 to ≤ 12 months), 0.084 ± 0.012 liters/kg/hr and 0.055 ± 0.006 liters/ kg/hr (1 to ≤ 2 years), and 0.065 ± 0.007 liters/kg/hr and 0.051 ± 0.001 liters/kg/hr (2 to ≤ 3 years), respectively. In all age groups, theophylline clearance of the pyrexia group was significantly less than that of the non-pyrexia group (p < 0.01), showing that there was a significant pharmacokinetic difference in theophylline clearance between the groups. Multivariate statistical analysis showed that theophylline clearance was affected by pyrexia and age. This study showed that the presence of pyrexia decreases theophylline clearance, and that it affects theophylline clearance in an age-dependent manner. Based on the results of this study, dosages should be designed based on the clearance at the time of pyrexia.
掲載誌名
Hiroshima Journal of Medical Sciences
61巻
1号
開始ページ
15
終了ページ
18
出版年月日
2012-03
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
(c) Hiroshima University Medical Press.
部局名
医歯薬学総合研究科
病院
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