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ID 46714
本文ファイル
著者
Yokoyama, Yuta 大学院医歯薬保健学研究院(薬)
Matsumoto, Kazuaki
Ikawa, Kazuro 大学院医歯薬保健学研究科(薬) 広大研究者総覧
Watanabe, Erika
Yamamoto, Hiroyuki
Imoto, Yutaka
Morikawa, Norifumi 大学院医歯薬保健学研究科(薬) 広大研究者総覧
Takeda, Yasuo
キーワード
ampicillin
sulbactam
cardiovascular surgery
prophylaxis
cardiopulmonary bypass
NDC
医学
抄録(英)
Antibiotic concentrations must be maintained at an adequate level throughout cardiovascular surgery to prevent surgical site infection. This study aimed to determine the most appropriate timing for intraoperative repeated dosing of ampicillin–sulbactam, a commonly used antibiotic prophylaxis regimen, to maintain adequate concentrations throughout the course of cardiovascular surgery with cardiopulmonary bypass (CPB). The total plasma concentrations of ampicillin were monitored in 8 patients after ampicillin (1 g)–sulbactam (0.5 g) administration via initial intravenous infusion and subsequent CPB priming. Pharmacokinetic parameters were estimated and used to predict the free plasma concentrations of ampicillin. The mean values for the volume of distribution, elimination rate constant, elimination half-life, and total clearance of ampicillin were 15.8±4.1 L, 0.505±0.186 h-1, 1.52±0.47 h, and 7.72±2.72 L/h, respectively. When ampicillin (1 g)–sulbactam (0.5 g) was intravenously administered every 3, 4, 6, and 12 h after the start of CPB, the predicted free trough plasma concentrations of ampicillin were 15.20, 8.25, 2.74, and 0.13 μg/mL, respectively. Therefore, an every-6-h regimen was needed to maintain the free ampicillin concentration at more than 2 μg/mL during cardiovascular surgery with CPB. We suggest that the dose and dosing interval for ampicillin–sulbactam should be adjusted to optimize the efficacy and safety of treatment, according to the minimum inhibitory concentrations for methicillin-sensitive Staphylococcus aureus isolates at each institution. Registration number: UMIN000007356.
掲載誌名
Biological and Pharmaceutical Bulletin
38巻
11号
開始ページ
1817
終了ページ
1821
出版年月日
2015-11-01
出版者
The Pharmaceutical Society of Japan
ISSN
0918-6158
1347-5215
NCID
出版者DOI
NAID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
Copyright (c) 2015 The Pharmaceutical Society of Japan
関連情報URL
部局名
医歯薬保健学研究科