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ID 34812
本文ファイル
著者
Michibata, Hitoshi
キーワード
Vanadium
Sulfate
Proton
Ascidian
Redox
Membrane transporters
NDC
生物科学・一般生物学
抄録(英)
Metal ions are required for physiologically essential functions such as metalloenzymatic reactions, redox reactions, electron transfer, regulation of transcription factor activity, and respiration in living cells. Generally, metal ions are homeostatically maintained at very low concentrations in the sub-micromolar to micromolar range in living cells. However, some organisms, called hyperaccumulators, collect extremely high levels of metal ions, thereby providing experimental systems in which to study the mechanisms underlying the selective accumulation of metal ions. Typical of such organisms are the ascidians, more commonly known as sea squirts or tunicates. They are sessile marine animals belonging to the chordates. Several species of ascidians are known to accumulate extremely high levels of vanadium ions in their blood cells. Vanadium is usually in the V-V state in the natural environment, but in ascidians, most of vanadium is reduced to V-III via V-IV during the assimilation process. In this review, we first summarize the history of the studies on vanadium accumulation in ascidians and then focus on the recent progress of molecular studies, especially on the transport and reduction of vanadium, using primarily two ascidian species, Ascidia sydneiensis samea and Ciona intestinalis. Several candidate genes for V-IV transporters and enzymes catalyzing the redox reactions of V-V/V-IV are addressed in detail. The function of accumulated V-III is discussed in relation to redox reactions. (C) 2011 Elsevier B.V. All rights reserved.
掲載誌名
Coordination Chemistry Reviews
255巻
19-20号
開始ページ
2249
終了ページ
2257
出版年月日
2011
出版者
Elsevier Science SA
ISSN
0010-8545
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
(c) 2011 Elsevier B.V. All rights reserved.
関連情報URL
部局名
理学研究科