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ID 21471
本文ファイル
著者
キーワード
kainate
l-proline
amino acid
ventrolateral medulla
arterial blood pressure
rat
NDC
医学
抄録(英)
Kainate is an excitatory amino acid receptor agonist with a structure similar to the amino acid L-proline. Our previous studies demonstrated that microinjections of L-proline into the ventrolateral medulla (VLM) of the rat induce a mapped pattern of blood pressure responses distinct from L-glutamate, and the depressor response to L-proline in the caudal VLM (CVLM) is abolished by the kainate/AMPA receptor antagonist CNQX. The present study investigated whether kainate produces the L-proline-mapped pattern of responses in the VLM, compared with the pattern by AMPA. Kainate is known to activate AMPA receptors at higher concentrations. Therefore, responses to kainate were investigated at a low concentration. Microinjections of AMPA or NMDA showed the pattern of the L-glutamate-type; a pressor response in the rostral VLM and caudal pressor area (CPA) and a depressor response in the CVLM. Microinjections of kainate showed depressor responses in the CVLM but minor pressor responses in the rostral VLM, suggesting the same responses to L-proline. However, the response sites in the CPA did not enable us to clearly determine the L-proline-type. Further trials at sites defined by a pressor response to L-glutamate in the CPA, successive injections Of L-proline and kainate produced no response, indicating that L-glutamate responding neurons in the CPA are not sensitive to L-proline and kainate. These results suggest that kainate stimulation in the VLM produces a mapped pattern of ABP responses similar to the mapped pattern with L-proline. Kainate receptors could therefore be involved in the depressor response to L-proline in the medulla.
掲載誌名
Neuroscience Letters
425巻
1号
開始ページ
12
終了ページ
17
出版年月日
2007-09
出版者
Elsevier Ireland Ltd
ISSN
0304-3940
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright(c) 2007 Elsevier Ireland Ltd
関連情報URL(IsVersionOf)
http://dx.doi.org/10.1016/j.neulet.2007.08.003
部局名
医歯薬学総合研究科