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ID 27714
本文ファイル
著者
Tsuda, Hidehiro
Kawaguchi, Hiroyuki
キーワード
Human pulp cells
interleukin-6
mitogen-activated protein kinases
neodymium-doped yttrium-aluminium-garnet laser
NDC
医学
抄録(英)
The anti-inflammatory effects of low-power laser irradiation have previously been reported. However, how the laser irradiation regulates the expression of inflammatory cytokines remains unknown. In the present study, to elucidate the mechanism behind the anti-inflammatory effect, we examined the effects of low-power neodymium-doped yttrium-aluminium-garnet (Nd:YAG) laser irradiation on interleukin (IL)-6 expression in human pulp (HP) cells stimulated by peptidoglycan (PGN) and focused on intracellular signaling pathways. Low-power Nd:YAG laser irradiation obviated the PGN-induced increase in IL-6 levels in HP cells. A p38 mitogen-activated protein kinase inhibitor, SB203580, also inhibited the increase in IL-6 messenger RNA levels. PGN stimulated the activity of phosphorylated p38 in HP cells. Low-power laser irradiation inhibited the activity. Thus, suppression of the phosphorylated p38 activity by low-power laser irradiation in HP cells culminates in inhibition of the increase in IL-6 induced by PGN, suggesting that low-power laser irradiation regulates intracellular signaling molecule activities to exert its anti-inflammatory effect. (J Endod 2009;35:373-376)
掲載誌名
Journal of Eenodontics
35巻
3号
開始ページ
373
終了ページ
376
出版年月日
2009
出版者
Elsevier Science INC
ISSN
0099-2399
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2009 American Association of Endodontists Published by Elsevier Inc.
関連情報URL
部局名
医歯薬学総合研究科