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ID 21564
本文ファイル
別タイトル
ラット一次知覚神経におけるCB1カンナビノイド受容体によるバニロイド受容体1活性の制御機構
著者
キーワード
CB1 cannabinoid receptor
dorsal root ganglion
protein kinase A
substance P
transient receptor potential vanilloid receptor 1
NDC
医学
抄録(英)
Cannabinoids have been reported to have analgesic properties in animals of acute nociception or of inflammatory and neuropathic pain models, but the mechanisms by which they exert such alleviative effects are not yet fully understood. We investigated whether the CB1- cannabinoid-receptor agonist HU210 modulates the capsaicin-induced 45Ca2+ influx and substance P like-immunoreactivity (SPLI) release in cultured rat dorsal root ganglion (DRG) cells. HU210 attenuated the capsaicin-induced 45Ca2+ influx and this effect was reversed by the CB1 antagonist AM251. Treatment of DRG cells with 100 nM bradykinin for 3 h potentiated capsaicin-induced SPLI release accompanied with the induction of cyclooxygenase-2 mRNA expression. The potentiation of SPLI release by bradykinin was reversed by HU210 or the protein kinase A (PKA) inhibitor H-89. HU210 also reduced forskolin-induced cyclic AMP production and forskolin-induced potentiation of SPLI release. These results suggest that CBi could inhibit either the capsaicin-induced Ca2+ influx or the potentiation of capsaicin-induced SPLI release by a long-term treatment with bradykinin through involvement of a cyclic-AMP-dependent PKA pathway. In conclusion, CBi-receptor stimulation modulates the activities of transient receptor potential vanilloid receptor 1 in cultured rat DRG cells.
内容記述
術後呼吸不全により診断された筋萎縮性側索硬化症の一例. 山田恭子, 井上徹英, 西岡憲吾, 日高昌三, 吉田敬. 麻酔と蘇生 31(3) 209-211, 睡眠時無呼吸を呈したHunter症候群の麻酔経験. 山田恭子, 中川五男, 久保田稔, 仁井内浩, 神谷達. 麻酔 46(7) 955-958, 塩酸ジルチアゼムが内頸静脈血酸素飽和度に及ぼす影響. 山田恭子, 中川五男, 久保田稔, 仁井内浩, 神谷達, 采谷英男, 酒井明彦. 麻酔 47(4) 410-413, Quantitative Measurement of Thromboelastography as a Function of Platelet Count. Kyoko Oshita,Toshiharu Az-ma, Yasuhiro Osawa and Osafumi Yuge. Anesth Analg 1999; 89: 296–9, 群発頭痛の治療法とその効果 : 10症例における検討. 大下恭子, 森脇克行, 福田秀樹, 前原康宏, 河本昌志, 弓削孟文. 麻酔と蘇生 37(1) 9-12, を付す。
ISSN
1347-8613
NCID
言語
英語
NII資源タイプ
学位論文
広大資料タイプ
学位論文
DCMIタイプ
text
フォーマット
application/pdf
権利情報
Copyright(c) by Author
学位記番号
甲第3613号
授与大学
広島大学(Hiroshima University)
学位名
博士(医学)
学位名の英名
Medicine
学位の種類の英名
doctoral
学位授与年月日
2005-03-21
部局名
医歯薬学総合研究科