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ID 37675
本文ファイル
著者
Mitsuoka, Takako
Kaseda, Yumiko
Yamashita, Hiroshi
Kohriyama, Tatsuo
Nakamura, Shigenobu
Yamamura, Yasuhiro
キーワード
Early-onset parkinsonism
Nicotine chewing gum
P300
UPDRS
NDC
医学
抄録(英)
It has been reported that nicotine shows some beneficial effects on Parkinson's disease. The purpose of the present study is to assess the therapeutic effects of nicotine chewing gum in patients with early-onset parkinsonism (EOP). The subjects were 8 patients with early-onset parkinsonism (male/ female = 4/ 4, mean age; 51.3 years). Four out of 8 patients had a history of smoking (smokers). To estimate the effects of nicotine gum, the scores on the Unified Parkinson's Disease Rating Scale (UPDRS) and auditory event-related potentials (ERPs) were studied before and after taking nicotine gum in the EOP patients. In smokers, UPDRS scores improved by more than 10 % and the P300 latency of auditory ERPs was shortened by more than 30 msec. In contrast, nicotine had no remarkable effects on UPDRS scores or auditory ERPs in non-smokers. We suggest that nicotine chewing gum may be a possible choice for the treatment of patients with EOP, especially when they are smokers.
掲載誌名
Hiroshima Journal of Medical Sciences
51巻
1号
開始ページ
33
終了ページ
39
出版年月日
2002-03
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
部局名
医歯薬学総合研究科
保健学研究科
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