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ID 20577
本文ファイル
著者
Yoshikawa, Kyoko
Tsukamoto, Mariko
Tamura, Namiko
キーワード
PTEN
Akt
Naphthoquinone
Menadione (vitamin K3)
NDC
医学
抄録(英)
Menadione (vitamin K3) has been shown to activate Erk in several cell lines. This effect has been shown to be due to the activation of EGF receptors (EGFR) as a result of inhibition of some protein tyrosine phosphatases. In the present study, we examined the effects of menadione on Akt in Chinese hamster ovary cells. The phosphorylation of Akt by menadione was not inhibited by AG1478, an inhibitor of EGFR. Menadione inhibited the lipid phosphatase activity of PTEN in a cell-free system. In an intact cell system, menadione inhibited the effect of transfected PTEN on Akt. Thus, one mechanism of its action was considered the accelerated activation of Akt through inhibition of PTEN. This was not the sole mechanism responsible for the EGFR-independent activation of Akt, because menadione attenuated the rate of Akt dephosphorylation even in PTEN-null PC3 cells. The decelerated inactivation of Akt, probably through inhibition of some tyrosine phosphatases, was considered another mechanism of its action.
掲載誌名
Biochimica et Biophysica Acta (BBA) - General Subjects
1770巻
4号
開始ページ
687
終了ページ
693
出版年月日
2007-04
出版者
Elsevier B.V.
ISSN
0304-4165
NCID
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2007 Elsevier B.V.
関連情報URL
部局名
医歯薬学総合研究科