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ID 33088
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別タイトル
Neural mechanism of P3-like potentials in rats <Summaries of the Doctoral Theses>
著者
キーワード
rat
event related potential
P3-like component
attention
anterior cingulate cortex (ACC)
hippocampus
NDC
医学
抄録(英)
P3 potentials have been widely used to study normal human cognitive functions and assess cognitive impairment in patients. However, several studies suggest that the usefulness of P3 potentials as practical assessment tools is limited, because their neural mechanisms remain unclear thus far. The aim of the present study was to investigate the neural mechanism of P3 potentials by using the socalled P3-like potentials in rats.

Chapter 1 presents a review of the relevant literature on the neural mechanisms of P3 potentials and P3-like potentials in animals.

In Chapter 2, we describe appropriate animal models to explain the neural basis of P3 potentials. The results of Experiments 1–5 demonstrate that rat P3-like potentials refl ect "attention processes," similar to human P3 potentials. Experiment 6 shows that rat P3-like potentials showed high reliability. Therefore, the rat model is useful for investigating the neural mechanisms underlying human P3 potentials.

Chapter 3 describes the investigations of the regions that generate P3 potentials, such as the ACC and hippocampus, conducted using the rat model. Experiment 7 showed that the latency of P3-like potentials from the ACC was shorter than that of potentials from the hippocampal CA1 region. Moreover, only highly deviant stimuli elicited P3-like amplitudes in the ACC, while the target stimulus elicited P3-like amplitudes in the hippocampal CA1 region, irrespective of stimulus deviation (Experiment 8).

In Chapter 4, on the basis of the results presented in chapters 2 and 3, a model describing the process of P3 generation is presented. Further, future studies are proposed.
掲載誌名
広島大学大学院総合科学研究科紀要. I, 人間科学研究
5巻
開始ページ
95
終了ページ
98
出版年月日
2010-12-31
出版者
広島大学大学院総合科学研究科
ISSN
1881-7688
NCID
言語
日本語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
Copyright (c) 2010 by Graduate School of Integrated Arts and Sciences, Hiroshima University All rights reserved
部局名
総合科学研究科
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