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ID 34930
本文ファイル
著者
Gotoh, Bin
Fujii, Yutaka
Yoshida, Tetsuya
キーワード
Hepatitis C Virus
Interferon
ISRE
GAS
NDC
医学
抄録(英)
Interferon is important for anti-viral defense of the host. The E2, NS3/4A, and NS5A proteins of hepatitis C virus (HCV) have recently been reported to confront anti-viral action induced by interferon. However, roles of the individual HCV proteins in anti-interferon action are still not well understood. We have isolated an HCV strain, HCV-K, from a patient with acute hepatitis. Nucleotide sequencing of the entire genomic DNA of HCV-K revealed that the isolate belongs to the genotype 1b, which is generally resistant to interferon therapy. In the present study, we expressed individual HCV-K proteins in mammalian cells and investigated effects of the proteins on interferon signal transduction. The results showed that the core, E1, NS4A, and NS4B proteins suppressed activation of interferon stimulation responsive element (ISRE) and gamma activation sequence (GAS) reporters. These results suggest that multiple HCV proteins have a function in suppression of the anti-viral effect by interferon and may indicate a novel role of E1 and NS4B proteins in interferon antagonism.
掲載誌名
Hiroshima Journal of Medical Sciences
55巻
3号
開始ページ
71
終了ページ
77
出版年月日
2006-09
出版者
Hiroshima University Medical Press
ISSN
0018-2052
NCID
言語
英語
NII資源タイプ
紀要論文
広大資料タイプ
学内刊行物(紀要等)
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
(c) Hiroshima University Medical Press.
部局名
医歯薬学総合研究科
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