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ID 34079
本文ファイル
著者
Kunita, Eiji
Yamamoto, Hideya 大学院医歯薬保健学研究院(医)
Ohashi, Norihiko
Oka, Toshiharu
Horiguchi, Jun
Awai, Kazuo 大学院医歯薬保健学研究院(医) 広大研究者総覧
Kihara, Yasuki 大学院医歯薬保健学研究院(医)
キーワード
Adiponectin
Computed tomography
Plaque
NDC
医学
抄録(英)
Background: Our group has previously reported that visceral adipose tissue (VAT) accumulation was associated with the extent and vulnerable characteristics of coronary plaques using coronary computed tomography angiography (CTA). An investigation of the associations between these coronary lesions with plasma adiponectin and leptin was performed.

Methods and Results: A total of 394 patients (220 men and 174 women) in the study were referred for CTA. Plain abdominal scanning was simultaneously performed to evaluate VAT areas. The median level of plasma high-molecular-weight (HMW) adiponectin in patients with CTA-based obstructive coronary artery disease was significantly lower than that in patients without (men: 1.45 vs. 1.88μg/ml, P=0.002; women: 2.49 vs. 3.44μg/ml, P<0.001). Multivariate analyses revealed that a lower HMW adiponectin concentration was significantly associated with the presence (men: P=0.019; women: P=0.018) and involved segment numbers (men: P=0.001; women: P=0.003) of coronary plaques. Furthermore, it was significantly related to coronary plaque with all 3 vulnerable characteristics of positive remodeling, low CT density (≤38 Hounsfield units), and adjacent spotty calcium (men: P=0.019; women: P=0.016). These associations were also observed with VAT areas, but not with plasma leptin concentrations, in both genders.

Conclusions: Lower plasma HMW adiponectin is associated with the presence, extent, and vulnerable characteristics of coronary plaques assessed by CTA in both genders.  (Circ J 2012; 76: 1687–1696)
掲載誌名
Circulation Journal
76巻
7号
開始ページ
1687
終了ページ
1696
出版年月日
2012
出版者
一般社団法人日本循環器学会
ISSN
1346-9843
NCID
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
Copyright (c) 2012 The Japanese Circulation Society.
関連情報URL
部局名
医歯薬学総合研究科