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ID 17103
本文ファイル
著者
Tamura, Hiroki
Kanamoto, Takashi
Kato, Tomoko
Sasaki, Ken
Izumi, Yuishin
Mishima, Hiromu K.
キーワード
Alzheimer's disease (AD)
Open-angle glaucoma (OAG)
Apolipoprotein E (APOE)
Intraocular pressure (IOP)
Japanese
Prevalence
Polymorphism
NDC
医学
抄録(英)
The clinical and genetic relationships between Alzheimer's disease (AD) and glaucoma remain obscure. The aim of this study was to determine the prevalence of open-angle glaucoma (OAG) in patients with AD and whether the apolipoprotein E (APOE) 4 allele is associated with AD, with or without OAG, in Japanese. The groups consisted of 172 patients with the diagnostic criteria of AD and 176 age-matched controls. Ophthalmic examinations were conducted, and genomic analysis was performed by PCR and digestion of products with an enzyme. OAG was found in 41 (23.8%) of the AD patients, which was a significantly (p=0.0002) higher prevalence than that in the controls (9.9%). Furthermore, there was no significant difference between intraocular pressures (IOPs) in AD patients with OAG and without OAG. The percentage of AD patients who carried an APOE ε4 allele (29.5%) was significantly (p=0.0007) higher than that of the controls (9.1%). However, the percentage of AD patients with OAG who carried an APOE ε4 allele (35.7%) was not significantly different than that of AD patients without OAG (27.7%, p=0.42). In summary, the prevalence of OAG is high in Japanese patients with AD, suggesting that common factors other than APOE may contribute to the two diseases.
掲載誌名
Journal of the Neurological Sciences
246巻
1-2号
開始ページ
79
終了ページ
83
出版年月日
2006-07-15
出版者
Elsevier
ISSN
0022-510X
NCID
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2006 Elsevier Ltd.
関連情報URL
部局名
原爆放射線医科学研究所