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ID 17114
本文ファイル
著者
Minakata, Hiroyuki
Takeshige, K.
Takata, T.
Matsushima, Osamu
Mukai, S.T.
Saleuddin, A.S.M.
Horiguchi, Toshihiro
キーワード
HPLC
purification
reproduction
imposex
organotin
NDC
生物科学・一般生物学
抄録(英)
The GGNG peptides are excitatory neuropeptides identified from earthworms, leeches and polychaeta. Two structurally related peptides were purified and characterized from a mollusk, Thais clavigera (prosobranch gastropod). The peptides designated as TEP-1 (Thais excitatory peptide-1) (KCSGKWAIHACWGGN-NH2) and TEP-2 (KCYGKWAMHACWGGN-NH2) are pentadecapeptides having one disulfide bond and C-terminal GGN-NH2 structures, which are shared by most GGNG peptides. TEP augmented the motilities of Thais esophagus and penial complex. TEP-like immunoreactivity is distributed in both the neurons of the central nervous system and nerve endings in the penial complex. Thus, the involvement of TEP in the contraction of the digestive and reproductive systems is suggested. Substitution of amino acids in TEP revealed that two tryptophan residues in TEP are important for maintaining bioactivity.
掲載誌名
Peptides
27巻
3号
開始ページ
483
終了ページ
492
出版年月日
2006-03
出版者
Elsevier
ISSN
0196-9781
NCID
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
author
権利情報
Copyright (c) 2006 Elsevier Ltd.
関連情報URL(IsVersionOf)
http://dx.doi.org/10.1016/j.peptides.2005.06.026
部局名
理学研究科