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ID 48182
本文ファイル
著者
Shibata, Sachi
Yatagai, Mitsuyoshi
Tateishi, Yoshiko
Matubara, Kiminori 大学院教育学研究科 広大研究者総覧
キーワード
Chamaecyparis pisifera
Cupressaceae
pisiferic acid
angiogenesis
lymphangiogenesis
endothelial cells
抄録(英)
Pisiferic acid, a diterpene isolated from Chamaecyparis pisifera, has a chemical structure similar to carnosic acid, which has antioxidant activity and exerts various biological effects such as antibiotic and antiangiogenic activity. However, the effect of pisiferic acid on angiogenesis, which is involved in various diseases including cancer and diabetic retinopathy, has not been elucidated. We found that pisiferic acid inhibited angiogenesis and suppressed human umbilical vein endothelial cell tube formation and proliferation but had no effect on human umbilical vein endothelial cell chemotaxis. Furthermore, in lymphangiogenesis assays, pisiferic acid inhibited lymphangiogenesis and lymphatic endothelial cell tube formation and proliferation. Together, these results suggest pisiferic acid to be a useful natural compound, such as carnosic acid, with beneficial effects on angiogenesisand lymphangiogenesis-related diseases.
内容記述
Supporting information available online at http://www.thieme-connect.de/products
This work was supported in part by grants from JSPS KAKENHI, grant numbers 22580130 and 26450159 (K.M.).
掲載誌名
Planta Medica International Open
3巻
02号
開始ページ
e31
終了ページ
e34
出版年月日
2016-08-22
出版者
Thieme Open
ISSN
2509‑6656
2199-157X
出版者DOI
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
© Georg Thieme Verlag KG Stuttgart · New York ·
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License.
関連情報
Planta Med Int Open 2016; 3: e31–e34
関連情報URL
部局名
教育学研究科