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ID 48181
本文ファイル
著者
Matsubara, Kiminori 大学院教育学研究科 広大研究者総覧
Kayashima, Tomoko
Mori, Masaharu
Yoshida, Hiromi
Mizushina, Yoshiyuki
キーワード
angiogenesis
aortic ring
endothelial cells
vitamin K3
抄録(英)
Vitamins play essential roles in cellular reactions and maintain human health. Recent studies have revealed that some vitamins including D3, B6 and K2 and their derivatives have an anti-cancer effect. As a mechanism, their inhibitory effect on cancer-related angiogenesis has been demonstrated. Vitamin K2 (menaquinones) has an anti-cancer effect in particular for hepatic cancer and inhibits angiogenesis. In the current study, we demonstrated that sole vitamin K3 (menadione) selectively inhibits the in vitro activity of eukaryotic DNA polymerase γ, which is a mitochondrial DNA polymerase, and suppresses angiogenesis in a rat aortic ring model. The anti-angiogenic effect of vitamin K3 has been shown in angiogenesis models using human umbilical vein endothelial cells (HUVECs) with regard to HUVEC growth, tube formation on reconstituted basement membrane and chemotaxis. These results suggest that vitamin K3 may be a potential anti-cancer agent like vitamin K2.
内容記述
This work was supported by the ‘Academic Frontier’ Project for Private Universities (Kobe-Gakuin University), matching fund subsidy from MEXT, 2006-2010, (K.M., H.Y. and Y.M.) and in part by a grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT). K.M. acknowledges a Grant-in-Aid for Young Scientists (B) (No. 18700608) from MEXT. Y.M. also acknowledges a Grant-in-Aid for Young Scientists (A) (No. 19680031) from MEXT, and Grants-in-Aid from the Nakashima Foundation and the Foundation of Oil & Fat Industry, Kaikan, Japan.
掲載誌名
International Journal of Molecular Medicine
22巻
3号
開始ページ
381
終了ページ
387
出版年月日
2008-09
出版者
Spandidos Publications
ISSN
1107-3756
1791-244X
出版者DOI
PubMedID
言語
英語
NII資源タイプ
学術雑誌論文
広大資料タイプ
学術雑誌論文
DCMIタイプ
text
フォーマット
application/pdf
著者版フラグ
publisher
権利情報
Copyright (c) 2008 Spandidos Publications UK Ltd.
関連情報
Matsubara, K., Kayashima, T., Mori, M., Yoshida, H., Mizushina, Y. "Inhibitory effects of vitamin K3 on DNA polymerase and angiogenesis". International Journal of Molecular Medicine 22, no. 3 (2008): 381-387.
関連情報URL
部局名
教育学研究科